托法替尼 Tofacitinib
交易須知
tofacitinib產(chǎn)品活性：tofacitinib是 jak1/2/3 抑制劑，ic50 分別為1，20 和 112 nm。
研究領(lǐng)域：epigenetics | stem cell/wnt | jak/stat signaling
作用靶點：jak
in vitro: tofacitinib (cp-690550) citrate binds potentially at jak3 and jak2 as 2.2 nm and 5 nm (kd). the report includes additional binding for tofacitinib at camk1 (kd of 5,000 nm), dcamkl3 (kd of 4.5 nm), mst2 (kd of 4,300 nm), pkn1 (kd of 200 nm), rps6ka2 (kin.dom.2-c-terminal) (kd of 1,400 nm), rps6ka6 (kin.dom.2-c-terminal) (kd of 1,200 nm), snark (kd of 420 nm), tnk1 (kd of 640 nm) and tyk2 (kd of 620 nm).
in vivo: animals that are treated with tofacitinib show a significantly lower production of anti-drug antibodies (adas) compare with peg-treated control mice (for five weeks after initial immunization, p<0.01, n=8). moreover adas become detectable earliest on day 28. a difference of 1000- to 200-fold in titers to ss1p is apparent from days 21 through 35, respectively. compare to ss1p, mice injected with keyhole limpet hemocyanin (klh) generate a more rapid antibody response. yet, the administration of tofacitinib reduces anti-klh titers compare to controls (p<0.05 on day 21, p4 hours.
相關(guān)產(chǎn)品：fda-approved drug library plus | drug repurposing compound library | fda-approved drug library mini | kinase inhibitor library | jak/stat compound library | stem cell signaling compound library | fda-approved drug library | drug repurposing compound library plus | epigenetics compound library | bioactive compound library plus | ruxolitinib | baricitinib | upadacitinib | tofacitinib citrate | momelotinib | pacritinib | chz868 | azd-1480 | at9283 | filgotinib | wp1066 | itacitinib | sb1317 | cerdulatinib | tyk2-in-4 | gandotinib | cucurbitacin i | pyridone 6 | peficitinib | delgocitinib | solcitinib | rgb-286638 free base | atractylenolide i | pf-06651600 | cep-33779 | decernotinib | tg101209 | az960
MedChemExpress LLC
鄭先生
86-021-58955995
17321200539
EBARA TFSQM PUMP現(xiàn)貨銷售
上城區(qū)潛能開發(fā)托班哪家好
TPU/德國拜耳/1154D50U 耐磨 透明級
清藍生物 白芍提取物 提取物
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托法替尼 Tofacitinib
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要想在網(wǎng)站推廣中取得成功，搜索引擎優(yōu)化是最為關(guān)鍵的一項任務(wù)
tofacitinib產(chǎn)品活性：tofacitinib是 jak1/2/3 抑制劑，ic50 分別為1，20 和 112 nm。
研究領(lǐng)域：epigenetics | stem cell/wnt | jak/stat signaling
作用靶點：jak
in vitro: tofacitinib (cp-690550) citrate binds potentially at jak3 and jak2 as 2.2 nm and 5 nm (kd). the report includes additional binding for tofacitinib at camk1 (kd of 5,000 nm), dcamkl3 (kd of 4.5 nm), mst2 (kd of 4,300 nm), pkn1 (kd of 200 nm), rps6ka2 (kin.dom.2-c-terminal) (kd of 1,400 nm), rps6ka6 (kin.dom.2-c-terminal) (kd of 1,200 nm), snark (kd of 420 nm), tnk1 (kd of 640 nm) and tyk2 (kd of 620 nm).
in vivo: animals that are treated with tofacitinib show a significantly lower production of anti-drug antibodies (adas) compare with peg-treated control mice (for five weeks after initial immunization, p<0.01, n=8). moreover adas become detectable earliest on day 28. a difference of 1000- to 200-fold in titers to ss1p is apparent from days 21 through 35, respectively. compare to ss1p, mice injected with keyhole limpet hemocyanin (klh) generate a more rapid antibody response. yet, the administration of tofacitinib reduces anti-klh titers compare to controls (p<0.05 on day 21, p4 hours.
相關(guān)產(chǎn)品：fda-approved drug library plus | drug repurposing compound library | fda-approved drug library mini | kinase inhibitor library | jak/stat compound library | stem cell signaling compound library | fda-approved drug library | drug repurposing compound library plus | epigenetics compound library | bioactive compound library plus | ruxolitinib | baricitinib | upadacitinib | tofacitinib citrate | momelotinib | pacritinib | chz868 | azd-1480 | at9283 | filgotinib | wp1066 | itacitinib | sb1317 | cerdulatinib | tyk2-in-4 | gandotinib | cucurbitacin i | pyridone 6 | peficitinib | delgocitinib | solcitinib | rgb-286638 free base | atractylenolide i | pf-06651600 | cep-33779 | decernotinib | tg101209 | az960
MedChemExpress LLC
鄭先生
86-021-58955995
17321200539
EBARA TFSQM PUMP現(xiàn)貨銷售
上城區(qū)潛能開發(fā)托班哪家好
TPU/德國拜耳/1154D50U 耐磨 透明級
清藍生物 白芍提取物 提取物
請問能加盟揚子木門嗎？
托法替尼 Tofacitinib
對焊大小頭管件-管件-長青管業(yè)
10G XFP DWDM光模塊-易飛揚Gigalight
龍之谷sf高防服務(wù)器租用
名信 發(fā)動機氣門積碳怎么清理
PERT管設(shè)計-不錯的PERT地暖管品牌介紹
房地產(chǎn)方向微信推廣如何可以脫穎而出—遼寧手機群A控自動微營銷
CYJ-1差壓計，CYJ-1型雙波紋管差壓液位計
武威鋼制智能檔案密集架廠家鋼之杰
縣城開艾森尼克RO膜店怎么樣？
供應(yīng)HZY-室內(nèi)PH3.91全彩顯示屏
中國股市最賺錢的一種人坦言：尾盤拉升有玄機，三種定式防出貨，摸透你就是股市高手
安信美家·君子蘭漆攜手共創(chuàng)家居環(huán)保新紀元
養(yǎng)魚技術(shù)：手把手傳授你，魚苗運輸及魚苗適時放養(yǎng)與密養(yǎng)注意事項
要想在網(wǎng)站推廣中取得成功，搜索引擎優(yōu)化是最為關(guān)鍵的一項任務(wù)